Defining at-risk populations for Parkinson's disease: lessons from ongoing studies.
Identifieur interne : 000E22 ( Main/Exploration ); précédent : 000E21; suivant : 000E23Defining at-risk populations for Parkinson's disease: lessons from ongoing studies.
Auteurs : Daniela Berg [Allemagne] ; Ken Marek ; George W. Ross ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical : Biological Markers.
- diagnosis : Parkinson Disease.
- etiology : Parkinson Disease.
- metabolism : Parkinson Disease.
- standards : Research Design.
- Early Diagnosis, Humans, Risk, Risk Factors.
Abstract
It is currently widely acknowledged that the natural history of PD includes a preclinical phase, and there are increasing efforts to identify markers that would allow the identification of individuals at risk for PD. Here, we discuss the issues related to defining at-risk populations for PD and review findings of current population-based cohorts that have reported potential biomarkers for PD, such as the Honolulu-Asia Aging Study (HAAS) and the PRIPS (Prospective Validation of Risk factors for the development of Parkinson Syndromes) study. We also discuss enriched risk cohorts designed to evaluate specificity and predictive value of markers exemplified by the PARS (Parkinson Associated Risk Study) and the TREND (Tübinger evaluation of Risk factors for the Early detection of NeuroDegeneration) study. Although there is still a long way to go, studies designed according to these concepts might eventually provide sufficient data to form the basis for future screening programs for PD risk to be applied at a population level.
DOI: 10.1002/mds.24985
PubMed: 22508284
Affiliations:
- Allemagne, Autriche
- Bade-Wurtemberg, District de Tübingen, Tyrol (Land)
- Innsbruck, Tübingen
- Université de médecine d'Innsbruck
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Le document en format XML
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Ross</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24985</idno><idno type="RBID">pubmed:22508284</idno><idno type="pmid">22508284</idno><idno type="wicri:Area/PubMed/Corpus">000E03</idno><idno type="wicri:Area/PubMed/Curation">000E03</idno><idno type="wicri:Area/PubMed/Checkpoint">000E64</idno><idno type="wicri:Area/Ncbi/Merge">003627</idno><idno type="wicri:Area/Ncbi/Curation">003627</idno><idno type="wicri:Area/Ncbi/Checkpoint">003627</idno><idno type="wicri:Area/Main/Merge">000E54</idno><idno type="wicri:Area/Main/Curation">000E22</idno><idno type="wicri:Area/Main/Exploration">000E22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Defining at-risk populations for Parkinson's disease: lessons from ongoing studies.</title><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center of Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany. daniela.berg@uni-tuebingen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center of Neurodegenerative Diseases, University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name></author><author><name sortKey="Ross, George W" sort="Ross, George W" uniqKey="Ross G" first="George W" last="Ross">George W. Ross</name></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological Markers</term><term>Early Diagnosis</term><term>Humans</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (metabolism)</term><term>Research Design (standards)</term><term>Risk</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biological Markers</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Research Design</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Early Diagnosis</term><term>Humans</term><term>Risk</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is currently widely acknowledged that the natural history of PD includes a preclinical phase, and there are increasing efforts to identify markers that would allow the identification of individuals at risk for PD. Here, we discuss the issues related to defining at-risk populations for PD and review findings of current population-based cohorts that have reported potential biomarkers for PD, such as the Honolulu-Asia Aging Study (HAAS) and the PRIPS (Prospective Validation of Risk factors for the development of Parkinson Syndromes) study. We also discuss enriched risk cohorts designed to evaluate specificity and predictive value of markers exemplified by the PARS (Parkinson Associated Risk Study) and the TREND (Tübinger evaluation of Risk factors for the Early detection of NeuroDegeneration) study. Although there is still a long way to go, studies designed according to these concepts might eventually provide sufficient data to form the basis for future screening programs for PD risk to be applied at a population level.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li><li>Tübingen</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><noCountry><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><name sortKey="Ross, George W" sort="Ross, George W" uniqKey="Ross G" first="George W" last="Ross">George W. Ross</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></region></country><country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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